Bacterial growth-mediated systems remodelling of Nicotiana benthamiana defines unique signatures of target protein production in molecular pharming. Nicholas Prudhomme, Rebecca Pastora, Sarah Thomson, Edison Zheng, Amanda Sproule, Jonathan R. Krieger, J. Patrick Murphy, David P. Overy, Doug Cossar, Michael D. McLean, Jennifer Geddes-McAlister. Plant Biotechnology Journal 22 March 2024
The emerging role of mass spectrometry-based proteomics in molecular pharming practices. Jennifer Geddes-McAlister, NicholasPrudhomme, Davier Gutierrez Gongora, DougCossar, Michael D.McLean. Current Opinion in Chemical Biology Volume 68, June 2022
Enhanced ability of plant-derived PGT121 glycovariants to eliminate HIV-1-infected cells. Sai Priya Anand, Shilei Ding, William D. Tolbert, Jérémie Prévost, Jonathan Richard, Hwi Min Gil, Gabrielle Gendron-Lepage, Wing-Fai Cheung, Haifeng Wang, Rebecca Pastora, Hirak Saxena, Warren Wakarchuk, Halima Medjahed, Bruce D. Wines, P. Mark Hogarth, George M. Shaw, Malcom A. Martin, Dennis R. Burton, Lars Hangartner, David T. Evans, Marzena Pazgier, Doug Cossar, Michael D. McLean, Andrés Finzi. Journal of Virology July 7, 2021
Quantitative proteomic profiling of shake-flask versus bioreactor growth reveals distinct responses of Agrobacterium tumefaciens for preparation in molecular pharming. Nicholas Prudhomme, Connor Gianetto-Hill, Rebecca Pastora, Wing-Fai Cheung, Emma Allen-Vercoe, Michael D McLean, Doug Cossar, Jennifer Geddes-McAlister. Canadian Journal of Microbiology 2020 Aug 26. doi: 10.1139/cjm-2020-0238. Online ahead of print.
Exposure of Agrobacterium tumefaciens to agroinfiltration medium demonstrates cellular remodeling and may promote enhanced adaptability for molecular pharming. Nicholas Prudhomme, Rebecca Pastora, Benjamin Muselius, Mike McLean, Doug Cossar, Jennifer Geddes-McAlister. Canadian Journal of Microbiology 2020 Jul 28. doi: 10.1139/cjm-2020-0239. Online ahead of print.
A Broad and Potent H1-Specific Human Monoclonal Antibody Produced in Plants Prevents Influenza Virus Infection and Transmission in Guinea Pigs. Jun-Gyu Park, Chengjin Ye, Michael S. Piepenbrink, Aitor Nogales, Haifeng Wang, Michael Shuen, Ashley J. Meyers, Luis Martinez-Sobrido, James J. Kobie. Viruses 020 Feb; 12(2): 167
Trastuzumab Made in Plants Using vivoXPRESS® Platform Technology. McLean MD. J Drug Des Res 4(5): 1052 (2017)
Plant-based Production of Biosimilar Drug Products. So Kenny KY, Marit MR, McLean MD, Hall JC. Chapter 17 in Biosimilar Drug Product Development, Eds. Endrenyi L, Declerck PJ, Chow SC.
The case for plant-made veterinary immunotherapeutics. Topp E, Irwin R, McAllister T, Lessard M, Joensuu JJ, Kolotilin I, Conrad U, Stöger E, Mor T, Warzecha H, Hall JC, McLean MD, Cox E, Devriendt B, Potter A, Depicker A, Virdi V, Holbrook L, Doshi K, Dussault M, Friendship R, Yarosh O, Yoo HS, MacDonald J, Menassa R. Biotechnology Advances, Sept.-Oct. 2016. 34 (5): 597-604.
Waiving in vivo studies for monoclonal antibody biosimilar development: National and global challenges. Kathryn Chapman, Akosua Adjei, Paul Baldrick, Antonio da Silva, Karen De Smet, Richard DiCicco, Seung Suh Hong, David Jones, Michael W. Leach, James McBlane, Ian Ragan, Praveen Reddy, Donald I. H. Stewart, Amanda Suitters, Jennifer Sims. mAbs journal, 06 February 2016
Bringing plant-based veterinary vaccines to market: Managing regulatory and commercial hurdles. Jacqueline MacDonald, Ketan Doshi, Marike Dussault, J. Christopher Hall, Larry Holbrook, Ginny Jones, Angelo Kaldis, Cassidy L. Klima, Phil Macdonald, Tim McAllister, Michael D. McLean, Andrew Potter, Alex Richman, Heather Shearer, Oksana Yarosh, Han Sang Yoo, Edward Topp, Rima Menassa. Biotechnology Advances, December 2015. 33 (8): 1572-81.
Plant-based solutions for veterinary immunotherapeutics and prophylactics. Igor Kolotilin, Ed Topp, Eric Cox, Bert Devreindt, Udo Conrad, Jussi Joensuu, Eva Stöger, Heribert Warzecha, Tim McAllister, Andrew Potter, Michael D McLean, J Christopher Hall, Rima Menassa. Veterinary Research 2014, 45:117, Dec. 31, 2014
In Vivo Neutralization of a-Cobratoxin with High-Affinity Llama Single-Domain Antibodies (VHHs) and a VHH-Fc Antibody. Richard G, Meyers AJ, McLean MD, Arbabi-Ghahroudi M, MacKenzie R, Hall JC. PLOS ONE, July 2013
Utility of the P19 suppressor of gene-silencing protein for production of therapeutic antibodies in Nicotiana expression hosts. Freydoun Garabagi, Erin Gilbert, Andreas Loos, Michael D. McLean and J. Christopher Hall. Plant Biotechnology Journal. Sept. 17, 2012
Purification of the therapeutic antibody trastuzumab from genetically modified plants using safflower Protein A-oleosin oilbody technology. Michael D. McLean, Rongji Chen, Deqiang Yu, Kor-Zheng Mah, John Teat, Haifeng Wang, Steve Zaplachinski, Joseph Boothe and J. Christopher Hall Transgenic Research, March 2, 2012
Recovery and isolation of recombinant human monoclonal antibody from transgenic tobacco plants. Mayani M, McLean MD, Hall, JC, Filipe, CDM, Ghosh, R. Biochemical Engineering Journal, April 15, 2011
Plant-Produced Trastuzumab Inhibits the Growth of HER2 Positive Cancer Cells. Grohs BM, Niu Y, Veldhuis LJ, Trabelsi S, Garabagi F, Hassell JA, McLean MD and Hall JC. Journal of Agricultural and Food Chemistry, Aug. 27, 2010
Purification of Plant-Derived Antibodies through Direct Immobilization of Affinity Ligands on Cellulose. Hussack G, Grohs BM, Almquist KC, McLean MD, Ghosh R, Hall JC. Journal of Agricultural and Food Chemistry, Feb. 19, 2010
Complexes with anti-epitope tag IgGs improve the therapeutic potential of epitope-tagged antibody fragments. Xie X, Weisser NE, McLean MD, Hall JC. Molecular Immunology, January 2010